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KMID : 1009020160140010109
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Clinical Psychopharmacology and Neuroscience
2016 Volume.14 No. 1 p.109 ~ p.113
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Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases
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Carlos Roncero
Raul Felipe Palma-Alvarez
Elena Ros-Cucurull
Carmen Barral
Begona Gonzalvo
Margarida Corominas-Roso
Miguel Casas
Lara Grau-Lopez
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Abstract
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Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.
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KEYWORD
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Cocaine-induced psychosis, Cocaine dependence, Brain-derived neurotrophic factor, Biological marker, Psychosis
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